之前自己编译的时候也碰到类似的问题， yum install openssl-devel 无用的说，源里的版本太旧了，要去官方自己下包编译。重要的几步找了下记录还在，供参考。
402 wget
http://www.openssl.org/source/openssl-1.0.2e.tar.gz 403 ./config --prefix=/usr --openssldir=/usr/local/openssl shared
404 tar zxf openssl-1.0.2e.tar.gz
405 cd openssl-1.0.2e
406 ./config --prefix=/usr --openssldir=/usr/local/openssl shared
407 make
408 make test
409 make install
410 cd ..
411 cd nginx-1.9.9
412 ./configure --prefix=/etc/nginx --sbin-path=/usr/sbin/nginx --conf-path=/etc/nginx/nginx.conf --error-log-path=/var/log/nginx/error.log --http-log-path=/var/log/nginx/access.log --pid-path=/var/run/nginx.pid --lock-path=/var/run/nginx.lock --http-client-body-temp-path=/var/cache/nginx/client_temp --http-proxy-temp-path=/var/cache/nginx/proxy_temp --http-fastcgi-temp-path=/var/cache/nginx/fastcgi_temp --http-uwsgi-temp-path=/var/cache/nginx/uwsgi_temp --http-scgi-temp-path=/var/cache/nginx/scgi_temp --user=nginx --group=nginx --with-http_ssl_module --with-http_realip_module --with-http_addition_module --with-http_sub_module --with-http_dav_module --with-http_flv_module --with-http_mp4_module --with-http_gunzip_module --with-http_gzip_static_module --with-http_random_index_module --with-http_secure_link_module --with-http_stub_status_module --with-http_auth_request_module --with-threads --with-stream --with-stream_ssl_module --with-mail --with-mail_ssl_module --with-file-aio --with-ipv6 --with-http_v2_module --add-module=../nginx-ct-master --with-openssl=/root/openssl-1.0.2e --with-cc-opt='-O2 -g -pipe -Wall -Wp,-D_FORTIFY_SOURCE=2 -fexceptions -fstack-protector-strong --param=ssp-buffer-size=4 -grecord-gcc-switches -m64 -mtune=generic'
413 make
414 make install